Neurogenin 1 antibody (N-Term)

Catalog No. ABIN357407

The Rabbit Polyclonal anti-Neurogenin 1 antibody has been validated for WB, IHC (p) and EIA. It is suitable to detect Neurogenin 1 in samples from Human.

Quick Overview for Neurogenin 1 antibody (N-Term) (ABIN357407)

Target: Neurogenin 1 (NEUROG1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurogenin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-Neurogenin 1 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects NeuroG1 at N-term.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human NeuroG1.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for Neurogenin 1

Target: Neurogenin 1 (NEUROG1)

Alternative Name: Neurogenin 1

Background: Basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.Synonyms: NEUROD3, NGN, NGN1, Neurogenic basic-helix-loop-helix protein, Neurogenic differentiation factor 3, Neurogenin 1

Molecular Weight: 25717 Da

Gene ID: 4762

NCBI Accession: NP_006152

UniProt: Q92886